The first original cathedral of Bovino dates back to the Constantinian era and was destroyed by Costante II in 663. The building was then rebuilt and renovated several times over the centuries. The current appearance is what the Gallic architect Zano imposed in the thirteenth century, using remnants of pagan temples and private and public buildings, harmonizing them with the material of the ancient cathedral. The façade, in squared stone ashlars, is a magnificent example of the advent of the Romanesque style in Apulia, even if it already anticipates styles proper to the Gothic and reuses previous decorative elements in the lunettes of the portals and in the vegetal motifs of the rosette, The polychrome stained glass window of Cristo Pantocratore was allocated to its centre following the reconstruction in 1960. Ai lati del rosone due colonnine tortili con leoni stilofori, mentre in corrispondenza della linea di colmo del tetto un toro con le corna spezzate. Il curioso aspetto asimmetrico va attribuito alla ricostruzione avvenuta dopo il terremoto del 1930.
The interior has a Latin cross, with a double-height central nave on the side naves and a presbytery raised by steps. In this factory was reused material of the bare Roman age, including imposing columns of granite, of different height, which was prepared with the use of bases of different sizes and workmanship (capitals and pulvins reused Roman). The bays are marked by a succession of round arches that are set directly on the Corinthian and Ionic capitals, of which some reused and others referable to the eighth-ninth century. The presbytery is decorated with an altar in marble and stone of Trani and a wooden choir seventeenth century, on which stands an organ pipe of the last century and a copy of the Annunciation of Titian.
Admirable are the two historiated shelves of the ninth century, arranged as capitals on the marble columns on the sides of the presbytery. In the right aisle, in a case, is placed the eighteenth-century devotional statue of Santa Maria di Valleverde, which is added to the thirteenth-century wooden kept in the Sanctuary of the same name.